Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk (2024)

View/Open: Author Accepted Manuscript (1.426Mb)

Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

URI: http://hdl.handle.net/10616/41405

Institution:

• MRC Human Genetics Unit, University of Edinburgh, Edinburgh, UK
• Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
• Wellcome Trust Centre for Human Genetics, Oxford, UK
• Department of Histopathology, Royal Devon and Exeter Hospital, Exeter, UK
• Public Health Sciences, University of Edinburgh, Edinburgh, UK
• Department of Psychology, University of Edinburgh, Edinburgh, UK
• Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
• Department of Surgical Oncology, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia
• Department of Surgery, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia
• Department of Medical Genetics, University of Helsinki, Helsinki, Finland
• Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
• Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä, Finland
• Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
• Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
• Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
• Translational Genomics Research Institute (TGen), Phoenix, AZ, USA
• Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
• Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
• Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia
• Department of Oncology, University of Cambridge, Cambridge, UK
• Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
• Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
• Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK
• Department of Oncology, Oxford University, Radcliffe Infirmary, Headington, Oxford, UK
• Oxford NIHR Comprehensive Biomedical Research Centre, Oxford, UK
• Family Cancer Clinic, St Mark's Hospital, Harrow and Imperial College, London, UK
• Department of Clinical Genetics, University of Birmingham, Birmingham, UK
• Department of Clinical Genetics, University of Manchester, Manchester, UK
• Institutionen för Kliniska Vetenskaper, Danderyds Sjukhus, Karolinska Institutet, Stockholm, Sweden
• Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

Citation DOI: 10.1038/ng.2293

Citation PMID: 22634755

Citation ISI: 000305886900010

Sponsorship:

• Cancer Research UK
• EU's Seventh Research Framework Programme (FP7)
• Wellcome Trust
• Juvenile Diabetes Research Foundation
• National Institute for Health and Care Research
• National Institute for Social Care and Health Research
• Leukaemia Lymphoma Research Fund
• Core Charity
• Medical Research Council
• Biotechnology and Biological Sciences Research Council
• Royal Society
• Chief Scientist Office of the Scottish Government
• Lifelong Health and Wellbeing Initiative
• Engineering and Physical Sciences Research Council
• Economic and Social Research Council
• Swedish Cancer Society
• Swedish Research Council
• Stockholm Cancer Foundation
• Academy of Finland
• Finnish Cancer Society
• Sigrid Juselius Foundation
• NIH National Cancer Institute
• Ministry of Education, Culture, Sports, Science and Technology, Japan

Publication year: 2012

Collections

• Artiklar / Articles
• Artiklar / Articles - D1 (KI DS)
• Artiklar / Articles - K1 (MMK)
• Artiklar / Articles - S1 (KI SÖS)
• Artiklar / Articles - SwePub